
%0 Journal Article
%A Brown, DJ 
%A Waring, P 
%T Simple pyrimidines. XVII. The effect of 4'(6')-substituents on the ionization of 2-(Pyrimidin-2'-yl)acetic acid
%J Australian Journal of Chemistry
%D 1978/03/01
%V 31
%N 3
%P 649-659
%K 
%R https://doi.org/10.1071/CH9780649
%U https://www.publish.csiro.au/paper/CH9780649 
%X The synthesis of a series of 4'-mono- and 4',6'-di-substituted derivatives of 2-(pyrimidin-2'-yl)acetic acid (1a) and the corresponding methyl esters is described. When allowance is made for the proportion of zwitterion present, the modified anionic pKa values of the monosubstituted acids show a reasonable correlation with an almost equal blend of the substituent parameters &#963;I and &#963;R+. The disubstituted acids show no such discernible correlation. 
