
TY  - JOUR
A1  - Brown, DJ 
A1  - Waring, P 
T1  - Simple pyrimidines. XVII. The effect of 4'(6')-substituents on the ionization of 2-(Pyrimidin-2'-yl)acetic acid
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1978
VL  - 31
IS  - 3
SP  - 649
EP  - 659
KW  - 
UR  - https://doi.org/10.1071/CH9780649 
N2  - The synthesis of a series of 4'-mono- and 4',6'-di-substituted derivatives of 2-(pyrimidin-2'-yl)acetic acid (1a) and the corresponding methyl esters is described. When allowance is made for the proportion of zwitterion present, the modified anionic pKa values of the monosubstituted acids show a reasonable correlation with an almost equal blend of the substituent parameters &#963;I and &#963;R+. The disubstituted acids show no such discernible correlation. 
ER  -

