
%0 Journal Article
%A Macleod, JK 
%A Worth, BR 
%A Wells, RJ 
%T Synthesis of benzofuranoid systems. IV. Total synthesis of cyperaquinone and conicaquinone
%J Australian Journal of Chemistry
%D 1978/07/01
%V 31
%N 7
%P 1533-1544
%K 
%R https://doi.org/10.1071/CH9781533
%U https://www.publish.csiro.au/paper/CH9781533 
%X The total synthesis of the novel naturally occurring benzodifuroquinones, cyperaquinone (1) and conicaquinone (2), starting from phloroglucinol is described. A comparison of synthetic and natural compounds confirmed the original structural assignments. The key intermediate in the synthesis was the 3-methylbenzofuran (21) which was prepared in high yield by an internal site-specific base-catalysed Ar1-5 cyclization of the acetonyloxy derivative (19). The method has also been applied to the syntheses of linear furocoumarins and dibenzofurans. 
