
%0 Journal Article
%A Deady, LW 
%A Stillman, DC 
%T Mechanisms for the acetylation of aminopyridines
%J Australian Journal of Chemistry
%D 1978/08/01
%V 31
%N 8
%P 1725-1730
%K 
%R https://doi.org/10.1071/CH9781725
%U https://www.publish.csiro.au/paper/CH9781725 
%X Rates of acetylation of aminopyridines and some ring methyl-substituted derivatives, with acetic anhydride in acetone at 36&#176;, are reported. The results indicate that rate-determining acetylation is directly at the amino nitrogen for all 2- and 3-aminopyridines studied. Reaction through a ring N-acetyl intermediate occurs for 4-aminopyridine but the presence of a 2-methyl substituent blocks this pathway. 
