
%0 Journal Article
%A Crumbie, RL 
%A Deol, BS 
%A Nemorin, JE 
%A Ridley, DD 
%T Asymmetric reduction of carbonyl compounds by yeast. IV. Preparation of optically active &#946;-hydroxy sulfides, sulfoxides and sulfones
%J Australian Journal of Chemistry
%D 1978/09/01
%V 31
%N 9
%P 1965-1980
%K 
%R https://doi.org/10.1071/CH9781965
%U https://www.publish.csiro.au/paper/CH9781965 
%X Reduction of simple &#946;-keto sulfides, &#946;-keto sulfoxides and P-keto sulfones by an actively fermenting mutant of Saccharomyces cerevisiae proceeds readily and affords good yields of the corresponding optically active secondary alcohols. For example, 1-(benzylthio)propan-2-one gave optically pure (S)-(+)-1-(benzylthio)propan-2-ol and 1- (phenylsulfonyl)propan-2-one gave optically pure (S)-(+)-1- (phenylsulfonyl)propan-2-ol. In the reductions of racemic &#946;-keto sulfoxides the enantiomers were reduced at sufficiently different rates to enable isolation of an optically active ketone and of an optically active &#946;-hydroxy sulfoxide. Hence, 1-(phenylsulfinyl)propan-2-one gave (S)-(-)-1-(phenyl-sulfinyl)propan-2-one and (RS,SC)-(+)-1- (phenylsulfinyl)propan-2-ol. 
