
%0 Journal Article
%A Jacobsen, NW 
%A McCarthy, BL 
%A Smith, S 
%T N-Aminopyrimidines: The Isomerization of 1-Aminobarbituric Acids to 2-(5-Oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl) Aliphatic Acids
%J Australian Journal of Chemistry
%D 1979/01/01
%V 32
%N 1
%P 161-165
%K 
%R https://doi.org/10.1071/CH9790161
%U https://www.publish.csiro.au/paper/CH9790161 
%X 1-Aminobarbituric acid undergoes a facile isomerization in aqueous acid to 2-(5-oxo-4,5-dihydro-lH-l,2,4-triazol-3-yl)acetic acid which in turn can be decarboxylated to give 3-methyl-1H-1,2,4- triazol-5(4H)-one. The isomerization reaction is shown to be a general one, adaptable to the synthesis of oxotriazolyl aliphatic acids and their decarboxylated products. A reaction mechanism for the isomerization is proposed. 
