
%0 Journal Article
%A Brown, DJ 
%A Danckwerts, L 
%A Grigg, GW 
%A Iwai, Y 
%T Purine Analogues as Amplifiers of Phleomycin. IV. Some Pyrazolo[3,4-d]pyrimidine, Imidazo[4,5-b]-pyridine, Imidazo[4,5-c]pyridine and Quinazoline Derivatives
%J Australian Journal of Chemistry
%D 1979/02/01
%V 32
%N 2
%P 453-458
%K 
%R https://doi.org/10.1071/CH9790453
%U https://www.publish.csiro.au/paper/CH9790453 
%X 1-Methyl-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-thione (1b), its 1-phenyl analogue (1c), 1H-pyrazolo- [3,4-dlpyrimidine-4,6(5H,7H)-dithione (2a), its 1-methyl (2b) and 1-phenyl (2c) derivatives, 1H-imidazo[4,5-b and 4,5-clpyridine-2(3H)-thiones (5) and (6), and quinazoline-4(3H)-thione (9) react with simple alkyl halides, 2-chloroacetamide, 2-chloro-N-methylacetamide or 2-bromopropionamide to give the corresponding thioethers (3e-n), (4a-1), (7a-c), (8a-d) and (10). The unmethylated amides among these show dual NH peaks in their n.m.r. spectra. Activities as amplifiers of phleomycin against E. coli are tabulated and discussed. 
