
TY  - JOUR
A1  - Bergmann, F 
A1  - Brown, DJ 
T1  - Methylation of Purin-8-ones
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1979
VL  - 32
IS  - 4
SP  - 859
EP  - 865
KW  - 
UR  - https://doi.org/10.1071/CH9790859 
N2  - In general, electrophilic alkylation of purin-8-ones takes place at the same sites as protonation. Exceptions are observed only for 3-methyl derivatives, in which cation formation involves N9, whereas methylation proceeds both at position 1 and 9. This dichotomy of alkylation is ascribed to steric interference between 3- and 9-methyl substituents. 
ER  -

