
TY  - JOUR
A1  - Healey, K 
A1  - Calder, IC 
T1  - The Synthesis and Reactions of N-Hydroxyparacetamol (N,4'-Dihydroxyacetanilide)
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1979
VL  - 32
IS  - 6
SP  - 1307
EP  - 1316
KW  - 
UR  - https://doi.org/10.1071/CH9791307 
N2  - The synthesis of N-hydroxyparacetamol (N,4'-dihydroxyacetanilide) is reported where a copper complex of the hydroxamic acids as a protecting group is used. It has been shown to decompose between pH 7 and 12 to give products which are derived from N-acetyl-p-benzoquinone imine.3'-Substituted 4'-hydroxyacetanilides are formed when a nucieophile is present. The properties of N-hydroxyparacetamol are consistent with it being the toxic, reactive intermediate involved in the hepatoxicity of paracetamol. 
ER  -

