
%0 Journal Article
%A Pitman, IH 
%A Morris, IJ 
%T Covalent Additions of Glutathione, Cysteine, Homocysteine, Cysteamine and Thioglycolic Acid to Quinazoline Cation
%J Australian Journal of Chemistry
%D 1979/07/01
%V 32
%N 7
%P 1567-1573
%K 
%R https://doi.org/10.1071/CH9791567
%U https://www.publish.csiro.au/paper/CH9791567 
%X A linear relationship with a gradient of 0·38 was found to exist between the &#947; values of thiols and the pKa values of their mercapto groups. The &#947; value of a nucleophilic reagent is a relative measure of the extent to which it will covalently add across >C=N-,>C=O and >C=C< groups, &#947; values for the thiols were calculated from the equilibrium constants for their covalent addition to quinazoline cation at 25º, l 0.1 M. The results indicate that substituents in a thiol influence both the pKa value of the mercapto group and the &#947; value in a similar manner but they have a significantly greater effect on the pKa value. 
