
TY  - JOUR
A1  - Pitman, IH 
A1  - Morris, IJ 
T1  - Covalent Additions of Glutathione, Cysteine, Homocysteine, Cysteamine and Thioglycolic Acid to Quinazoline Cation
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1979
VL  - 32
IS  - 7
SP  - 1567
EP  - 1573
KW  - 
UR  - https://doi.org/10.1071/CH9791567 
N2  - A linear relationship with a gradient of 0·38 was found to exist between the &#947; values of thiols and the pKa values of their mercapto groups. The &#947; value of a nucleophilic reagent is a relative measure of the extent to which it will covalently add across >C=N-,>C=O and >C=C< groups, &#947; values for the thiols were calculated from the equilibrium constants for their covalent addition to quinazoline cation at 25º, l 0.1 M. The results indicate that substituents in a thiol influence both the pKa value of the mercapto group and the &#947; value in a similar manner but they have a significantly greater effect on the pKa value. 
ER  -

