
TY  - JOUR
A1  - Armarego, WLF 
A1  - Tucker, PG 
T1  - Quinazolines. XXIV. The Synthesis of 2,4-Diazatetra-cyclo[7,3,1,1<sup>7,11</sup>,0<sup>1,6</sup>]tetradecanes(Adamantano [1,2-d]pyrimidines)
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1979
VL  - 32
IS  - 8
SP  - 1805
EP  - 1817
KW  - 
UR  - https://doi.org/10.1071/CH9791805 
N2  - The syntheses of 6-hydroxy-2,4-Diazatetracyclo[7,3,1,17,11,01,6]tetradecan-3-iminium (4) picrate and related compounds starting from 2-oxoadamantane-1-carbonyl chloride (5) are described. In preliminary biological evaluation it was found that the most toxic (M.L.D. values for mice) adamantane derivative, 3,5 diazatetracyclo[7,3,1,17,11,01,6]tetradecane-2,4-dione (76 mg kg-1), was much less toxic than tetrodotoxin (0.013 mg kg-1). 
ER  -

