
TY  - JOUR
A1  - Lister, JH 
T1  - Purine Studies. XXII. Occurrence of N- and C-Methylation on Diazomethane Treatment of 2-Methylthiopurine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1979
VL  - 32
IS  - 12
SP  - 2771
EP  - 2776
KW  - 
UR  - https://doi.org/10.1071/CH9792771 
N2  - Diazomethane treatment of 2-methylthiopurine gives the expected 9- methyl-2-methylthiopurine as the main product together with a smaller amount of the 7-methyl isomer. An unexpected feature of this reaction, however, is the formation also, in smaller but significant yields, of C,N-dimethylated homologues, identified as 7,8- and 8,9-dimethyl-2- methylthiopurine. Subsequent methylation studies point towards the 8-methyl group in the latter derivatives being introduced prior to the N-methylation step, thus representing an additional alkylation pathway for some purine derivatives. 
ER  -

