
%0 Journal Article
%A Stewart, FHC 
%T Synthesis of L-Kynurenine peptides conducted without masking the side-chain amino group
%J Australian Journal of Chemistry
%D 1980/03/01
%V 33
%N 3
%P 633-640
%K 
%R https://doi.org/10.1071/CH9800633
%U https://www.publish.csiro.au/paper/CH9800633 
%X Various free L-kynurenine peptides, including an analogue of the opiate agonist leucine-enkephalin, have been synthesized by using the N&#945;-t- butyloxycarbonyl derivative of L-kynurenine as a key precursor. By selecting appropriate mild conventional coupling procedures it was possible to carry out the synthetic operations without having to mask the side-chain amino group in any way, but intramolecular acylation with formation of a seven-membered lactam could be demonstrated under more vigorous conditions. 
