
TY  - JOUR
A1  - Fenn, MD 
A1  - Lister, JH 
T1  - Purine studies. XXIII. Conformational aspects of N-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-y1)formamides and related N-benzyl derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1980
VL  - 33
IS  - 7
SP  - 1611
EP  - 1617
KW  - 
UR  - https://doi.org/10.1071/CH9801611 
N2  - The occurrence of 'Z' and 'E' conformers in 5-formamidouracil derivatives has been investigated by 1H n.m.r. and the effect of the nature and size of the substituents on the isomer ratio studied. Also considered was the relative steric competition between the benzyl and uracil moieties. As it is known that cyclic substituents with groups located ortho to the formamido group can induce rotation of the plane of the latter group into an orthogonal position to the plane of the ring, evidence for a corresponding effect in the case of the 6- aminouracil derivatives was sought. Similar but more restricted studies have been made with related 5-thioureidouracil analogues. 
ER  -

