
%0 Journal Article
%A Radom, L 
%A Riggs, NV 
%T <I>Ab initio</I> studies on amides: conformational preferences of diacetamide and barriers to interconversion of the conformers
%J Australian Journal of Chemistry
%D 1980/11/01
%V 33
%N 11
%P 2337-2342
%K 
%R https://doi.org/10.1071/CH9802337
%U https://www.publish.csiro.au/paper/CH9802337 
%X Diacetamide, like other diacylamines, is capable of existing in three basic conformations about the N-C bonds. Optimization (STO-3G) of model systems in which all first-row atoms and the amido hydrogen atom are held coplanar predicts that the E,Z conformer (3) is of lowest energy, the Z,Z conformer (2) of somewhat higher energy (4.2 kJ mol-1), and the E,E conformer (1) of highest energy (23.6 kJ mol-1); 4-31G evaluation of the energies suggests that (1) and (2) are each of higher energy than (3) by 27-28 kJ mol-1. It is suggested that (2) is destabilized with respect to (3) by electrostatic repulsion of the two negatively charged oxygen atoms whereas destabilization of (1) is due to substantial methyl-methyl steric interactions as reflected in the very wide <CNC (136&#176;); the energy of (1) is, however, raised by out-of-plane or rotational movements of the methyl groups, i.e., the preferred structure (excluding methyl hydrogens) is planar. The calculated height of the barrier to internal rotation of (3) by either of two model transition states is 41-45 kJ mol-1, in good agreement with an experimental value of 45.2 kJ mol-1 in solution at -60&#176;. 
