
%0 Journal Article
%A Hutchison, GI 
%A Marshall, PA 
%A Prager, RH 
%A Tippett, JM 
%A Ward, AD 
%T Central nervous system active compounds. IV. Synthesis of 3-aminobenzylphthalides
%J Australian Journal of Chemistry
%D 1980/12/01
%V 33
%N 12
%P 2699-2715
%K 
%R https://doi.org/10.1071/CH9802699
%U https://www.publish.csiro.au/paper/CH9802699 
%X Several 3-aminobenzylphthalides have been prepared by reactions of 3- (2-oxo-1-phenylpropyl)-phthalides with hydrazoic acid or by the Beckmann rearrangement. The corresponding reactions with 3-(2- oxoindanyl)phthalides showed limited success but led to a new synthesis of phthalide-isoquinoline alkaloids. Preliminary biological testing of some of these derivatives indicates that they only have weak central nervous system activity. 
