
%0 Journal Article
%A Hung, TV 
%A Mooney, BA 
%A Prager, RH 
%A Tippett, JM 
%T Central nervous system active compounds. VII. Phthalide synthesis by lithiation of alkoxyaromatics
%J Australian Journal of Chemistry
%D 1981/02/01
%V 34
%N 2
%P 383-395
%K 
%R https://doi.org/10.1071/CH9810383
%U https://www.publish.csiro.au/paper/CH9810383 
%X The lithiation of methoxy- and methylenedioxy-bemyl alcohols is described; subsequent reactions with ethyl chloroformate and carbon dioxide to form phthalides have been investigated, and are compared with metallation-carboxylation of alternative substrates. The preparation of phthalideisoquinoline analogues by this method proceeds only in low yields due to the acidity of the benzylic position in the benzylisoquinoline precursor. 
