
%0 Journal Article
%A Boreham, CJ 
%A Broomhead, JA 
%A Fairlie, DP 
%T A <sup>195</sup>Pt and <sup>15</sup>N N.M.R. study of the anticancer drug, <I>cis</I>-diammine-dichloroplatinum(II), and its hydrolysis and oligomerization products
%J Australian Journal of Chemistry
%D 1981/03/01
%V 34
%N 3
%P 659-664
%K 
%R https://doi.org/10.1071/CH9810659
%U https://www.publish.csiro.au/paper/CH9810659 
%X 195Pt and 15N n.m.r, spectra for aqueous solutions of the anti-cancer drug cis-diamminedichloroplatinum(II) and its hydrolysis and oligomerization products are reported. In the blood substituteHanks medium, conversion of cis-[Pt(15NH3)2(H20)2](NO3)2 into cis[PtCl2(15NH3)2], cis-[PtCl(H20)(15NH3)2]+,[Pt(15NH3)2OH]33+ and [Pt(15NH3)2OH]22+ has been observed, the reaction taking several hours at 30ºC. In 0.15 M sodium chloride, both [Pt(NH3)2OH]33+ and[Pt(NH3)2OH]22+ are converted overnight into cis-[PtCl(H2O)(NH3)2]+. The infrared bands at 546 and 522 cm-1 in [Pt(NH3)2OH]2SO4 and at 520 cm-1 in [Pt(NH3)2OH]2(SO4)3 have been reassigned to Pt-N modes. 
