
%0 Journal Article
%A Armarego, WLF 
%A Waring, P 
%T Pterins. VII. Preparation of 6,6-dimethyl-5,6,7,8-tetrahydropterin hydrochloride
%J Australian Journal of Chemistry
%D 1981/09/01
%V 34
%N 9
%P 1921-1933
%K 
%R https://doi.org/10.1071/CH9811921
%U https://www.publish.csiro.au/paper/CH9811921 
%X The preparation of 6,6-dimethyl-5,6,7,8-tetrahydropterin (5) hydrochloride, a possible substrate for the phenylalanine hydroxylating system, has been achieved by trimethylsilylating 6-methyl-7,8- dihydropterin, reacting with methyllithium and removing the trimethylsilyl groups. Attempts to prepare this pterin by intramolecular cyclization of 2,5-diamino-6-(2'-hydroxy-2'-methylpropyl)-aminopyrimidin-4(3H)-one (17) gave the isomeric 5,8-diamino-3,3-dimethyl-2,3-dihydroimidazo- [1,2-clpyrimidin-7(1H)-one (20). 
