
TY  - JOUR
A1  - Mander, LN 
A1  - Woolias, M 
T1  - Studies on reductive alkylation. Regiocontrolled synthesis of anthracene derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1981
VL  - 34
IS  - 10
SP  - 2249
EP  - 2252
KW  - 
UR  - https://doi.org/10.1071/CH9812249 
N2  - Reductive alkylation of 2,5-dimethoxybenzoic acid, its 4-methyl derivative, and 3,5-dimethoxybenzoic acid with methyl 2-iodomethyl-6-methoxybenzoate furnished acids (I), (2) and (3),respectively. Oxidative decarboxylation followed by hydrolysis led to diphenylmethane acids (4),(5) and (6). Cycloacylation of (4) and (5) gave 1,4,8-trimethoxyanthracen-9-ol (7) and its 2-methyl derivative (8), thereby serving as models for a regiocontrolled synthesis of anthracyclines. Cycloacylation of (6) could only be achieved with concomitant C-acylation, to give 4-acetyl-1,3,8-trimethoxyanthracen-9-yl acetate (9). 
ER  -

