
%0 Journal Article
%A Brown, DJ 
%A Buttler, BB 
%A Cowden, WB 
%A Grigg, GW 
%A Kavulak, D 
%A Podger, DM 
%T Unfused heterobicycles as amplifiers of phleomycin. III. Thiazolylpyridines and bipyrimidines with strongly basic side chains
%J Australian Journal of Chemistry
%D 1981/11/01
%V 34
%N 11
%P 2423-2429
%K 
%R https://doi.org/10.1071/CH9812423
%U https://www.publish.csiro.au/paper/CH9812423 
%X Syntheses are described for 4-(thiazol-4'-yl)pyridines, each 2'-substituted by a dialkylaminoalkyl, dialkylaminoalkylthio or dialkylaminoalkylamino side chain; for 2- and 3-(thiazol-4'-yl)pyridines with a 2'-dimethylaminoethylthio substituent; for 4-(thiazol-2'-yl)pyridines with either a 4'- or a 5'-dialkylaminoalkylcarbamoyl substituent; and for some analogous compounds. The above and similarly substituted 2,4'-, 4,5'- and 5,5'-bipyrimidines have been screened for activity as amplifiers of phleomycin-G against Escherichia coli B by an improved in vitro procedure. The results are tabulated and discussed. 
