
%0 Journal Article
%A Galbraith, M 
%A Horn, DS 
%A Kelly, B 
%A Kinnear, J 
%A Martin, M 
%A Middleton, E 
%A Virgona, CF 
%T Moulting Hormones. LIII. the Synthesis and Biological Activity of Some Ecdysone Analogues
%J Australian Journal of Chemistry
%D 1981/12/01
%V 34
%N 12
%P 2607-2618
%K 
%R https://doi.org/10.1071/CH9812607
%U https://www.publish.csiro.au/paper/CH9812607 
%X A number of ecdysone analogues were prepared to study the effect of structural changes on biological activity. It was found that analogues with the 5&#945;-configuration or a 3,5-cyclo structure were inactive, that a 3&#946;-hydroxy group enhances activity but is not essential for activity, and that 3&#946;-substituents decrease activity as follows: OMe (60%), OAc (25%) and OEt (10%). The keto diol (3), keto alcohol (9) and amide (36) were found to be highly toxic to mosquito larvae. 
