
TY  - JOUR
A1  - Gan, Chee Yong 
A1  - Lambert, John N. 
A1  - Gable, Robert W. 
T1  - Exploration of the Patern&#242;&#8211;B&#252;chi Reaction as a Potential Route to the Oxetan Ring of Taxol<emph type="7">&#174;</emph>
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1999
VL  - 52
IS  - 7
SP  - 629
EP  - 638
KW  - 
UR  - https://doi.org/10.1071/CH98160 
N2  - Two photochemical pathways to paclitaxel-like oxetan rings have been examined. In the first approach, an intramolecular Patern&ograve;&#8211;B&#220;chi reaction on a 6,7-enal was attempted without success. The intermolecular variation using a bicyclic alkene in the presence of either benzaldehyde or acetophenone delivered oxetans whose regiochemistry was the same as that found in paclitaxel but opposite in stereochemistry. The crystal structures of a key intermediate diol and a photochemically generated oxetan are reported. 
ER  -

