
%0 Journal Article
%A Gallagher, MJ 
%A Honegger, H 
%A Sussman, J 
%T Organophosphorus intermediates. VIII. The synthesis of some 2,6-dioxo-1,2,3,4,6,7,8,8a-octahydro-2&#955;<sup>5</sup>-isophosphinoline derivatives
%J Australian Journal of Chemistry
%D 1982/02/01
%V 35
%N 2
%P 363-371
%K 
%R https://doi.org/10.1071/CH9820363
%U https://www.publish.csiro.au/paper/CH9820363 
%X Methyl 1-methoxy-1,4-dioxo-1&#955;5-phosphorinan-3-carboxylate (3) adds readily to but-3-en-2-one to give an adduct (5) which cyclizes under mild non-aqueous conditions to the novel tricyclic compound(6). Substance (5) may be cyclized to mixtures of bicyclic derivatives with either acid or base but the combination LiL/LiOH affords 2-hydroxy-1,2,3,4,8,8a-hexahydroisophosphinolin-6(7H)-one 2-oxide (7a) in an overall yield of 65%. 1H, 13C and 31P n.m.r., and mass spectra are reported and discussed. 
