
TY  - JOUR
A1  - Gallagher, MJ 
A1  - Honegger, H 
A1  - Sussman, J 
T1  - Organophosphorus intermediates. VIII. The synthesis of some 2,6-dioxo-1,2,3,4,6,7,8,8a-octahydro-2&#955;<sup>5</sup>-isophosphinoline derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1982
VL  - 35
IS  - 2
SP  - 363
EP  - 371
KW  - 
UR  - https://doi.org/10.1071/CH9820363 
N2  - Methyl 1-methoxy-1,4-dioxo-1&#955;5-phosphorinan-3-carboxylate (3) adds readily to but-3-en-2-one to give an adduct (5) which cyclizes under mild non-aqueous conditions to the novel tricyclic compound(6). Substance (5) may be cyclized to mixtures of bicyclic derivatives with either acid or base but the combination LiL/LiOH affords 2-hydroxy-1,2,3,4,8,8a-hexahydroisophosphinolin-6(7H)-one 2-oxide (7a) in an overall yield of 65%. 1H, 13C and 31P n.m.r., and mass spectra are reported and discussed. 
ER  -

