
%0 Journal Article
%A Cruz, R 
%A Martinez, RM 
%T Stereoselective total synthesis of (&#177;)-isocostic and (&#177;)-3-oxoisocostic acids
%J Australian Journal of Chemistry
%D 1982/02/01
%V 35
%N 2
%P 451-456
%K 
%R https://doi.org/10.1071/CH9820451
%U https://www.publish.csiro.au/paper/CH9820451 
%X Stereoselective total synthesis of the title compounds, two new sesquiterpenes isolated from a Mexican plant, are described. The key step in the synthesis is based on classical santon in syntheses by the stereoselective Michael addition of the potassium salt of ethyl &#945;-cyanoacetate to the dienone(4), to give the cis adduct (5), in an 8 : 2 ratio with the trans isomer. Further appropriate transformation of this cis adduct (5) leads to formation of either isocostic acid (1) or 3-oxoisocostic acid (2). 
