
TY  - JOUR
A1  - Cruz, R 
A1  - Martinez, RM 
T1  - Stereoselective total synthesis of (&#177;)-isocostic and (&#177;)-3-oxoisocostic acids
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1982
VL  - 35
IS  - 2
SP  - 451
EP  - 456
KW  - 
UR  - https://doi.org/10.1071/CH9820451 
N2  - Stereoselective total synthesis of the title compounds, two new sesquiterpenes isolated from a Mexican plant, are described. The key step in the synthesis is based on classical santon in syntheses by the stereoselective Michael addition of the potassium salt of ethyl &#945;-cyanoacetate to the dienone(4), to give the cis adduct (5), in an 8 : 2 ratio with the trans isomer. Further appropriate transformation of this cis adduct (5) leads to formation of either isocostic acid (1) or 3-oxoisocostic acid (2). 
ER  -

