
%0 Journal Article
%A Brown, DJ 
%A Cowden, WB 
%T Unfused heterobicycles as amplifiers of phleomycin. V. A range of pyridinylpyrimidines with strongly basic side chains
%J Australian Journal of Chemistry
%D 1982/06/01
%V 35
%N 6
%P 1203-1207
%K 
%R https://doi.org/10.1071/CH9821203
%U https://www.publish.csiro.au/paper/CH9821203 
%X The condensation of 3-aminocrotonamide with ethyl pyridine-2-carboxylate or a related ester gave 6-methylpyrimidin-4(3H)-ones, each bearing at its 2-position a pyridin-2'-yl, pyridin-3'-yl, pyridin- 4'-yl, furan-2'-yl, furan-3'-yl, thien-2'-yl or pyrazin-2'-yl substituent. Of these, the pyridinyl derivatives (1a), (2a) and (3a) were converted into their 4-chloro analogues and thence by nucleophilic displacement into the corresponding &#946;-dimethylaminoethylthio, &#946;-dimethylaminoethylamino, &#946;-dimethylaminoethoxy and &#947;-dimethylaminopropylamino derivatives. The activities of these compounds as amplifiers of phleomycin against Escherichia coli are reported. 
