
TY  - JOUR
A1  - Brown, DJ 
A1  - Cowden, WB 
T1  - Unfused heterobicycles as amplifiers of phleomycin. V. A range of pyridinylpyrimidines with strongly basic side chains
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1982
VL  - 35
IS  - 6
SP  - 1203
EP  - 1207
KW  - 
UR  - https://doi.org/10.1071/CH9821203 
N2  - The condensation of 3-aminocrotonamide with ethyl pyridine-2-carboxylate or a related ester gave 6-methylpyrimidin-4(3H)-ones, each bearing at its 2-position a pyridin-2'-yl, pyridin-3'-yl, pyridin- 4'-yl, furan-2'-yl, furan-3'-yl, thien-2'-yl or pyrazin-2'-yl substituent. Of these, the pyridinyl derivatives (1a), (2a) and (3a) were converted into their 4-chloro analogues and thence by nucleophilic displacement into the corresponding &#946;-dimethylaminoethylthio, &#946;-dimethylaminoethylamino, &#946;-dimethylaminoethoxy and &#947;-dimethylaminopropylamino derivatives. The activities of these compounds as amplifiers of phleomycin against Escherichia coli are reported. 
ER  -

