
%0 Journal Article
%A Brown, DJ 
%A Cowden, WB 
%A Strekowski, L 
%T Unfused heterobicycles as amplifiers of phleomycin. VI. Some thienyl- and thiazolyl-pyrimidines with strongly basic side chains
%J Australian Journal of Chemistry
%D 1982/06/01
%V 35
%N 6
%P 1209-1214
%K 
%R https://doi.org/10.1071/CH9821209
%U https://www.publish.csiro.au/paper/CH9821209 
%X 2-Chloro-4-(thien-2'-yl)pyrimidine (2a) and its thiazol-2'-yl analogue (2d) are prepared by condensation of 2-chloropyrimidine with thien-2-yl- and thiazol-2-yl-lithium, followed by oxidation of the dihydro intermediates. 4-Chloro-6-methyl-2-(thien-2'-yl)pyrimidine (3b),its 2-(2',4'-dimethylthiazol-5'-yl) analogue (3f) and the 2-(2'-methylthiazol-4'-yl) analogue (4b) are made from the corresponding pyrimidinones, which are available by primary synthesis. Each chloro compound is converted by nucleophilic displacement into its &#946;-dimethylaminoethylamino and &#946;-dimethylaminoethylthio derivatives, for which activities as amplifiers of phleomycin are reported and  discussed. 
