
%0 Journal Article
%A Cowden, WB 
%A Jacobsen, NW 
%A Stunzi, H 
%T Pyrimidine N-oxides. V. Ionization constants of N-hydroxybarbiturates
%J Australian Journal of Chemistry
%D 1982/06/01
%V 35
%N 6
%P 1251-1253
%K 
%R https://doi.org/10.1071/CH9821251
%U https://www.publish.csiro.au/paper/CH9821251 
%X The ionization constants, pKa, of a number of N-hydroxy 5-substituted barbituric acids and their O-and N-alkylated derivatives are reported. For practical comparisons under physiological conditions, pKa values were also determined at I 0.15 M KNO3 and 37º for the clinically useful barbiturates metharbital, phenobarbital and veronal, and for their mono-N-hydroxy derivatives. The pKa values for N,N?-dihydroxyphenobarbital and the corresponding veronal were also measured. 
