
%0 Journal Article
%A Gellert, E 
%A Kumar, N 
%A Tober, D 
%T Stereospecific synthesis of tetrahydrobenzisoquinoline derivatives
%J Australian Journal of Chemistry
%D 1983/01/01
%V 36
%N 1
%P 157-163
%K 
%R https://doi.org/10.1071/CH9830157
%U https://www.publish.csiro.au/paper/CH9830157 
%X A new synthesis of optically active tetrahydrobenzisoquinolines is described. Cyclization of N-aryl- alkylalanines with retention of configuration was achieved by mild intramolecular Friedel-Crafts acylation. The compounds synthesized this way represent simple analogues of phenanthroindolizidine alkaloids. Some features of the n.m.r. spectra of cyclized and open-chain intermediates are discussed. 
