
TY  - JOUR
A1  - Allan, RD 
A1  - Fong, J 
T1  - Synthesis of analogues of GABA. VIII. Selective a-alkylation and &#947;-halogenation of the dianion from &#945;,&#946;-unsaturated nipecotic acid derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1983
VL  - 36
IS  - 3
SP  - 601
EP  - 608
KW  - 
UR  - https://doi.org/10.1071/CH9830601 
N2  - 1,2,3,6-Tetrahydropyridine-3-carboxylic acid (3), the &#946;, &#947;-unsaturated derivative of the GABA uptake inhibitor nipecotic acid (1), has been synthesized by deconjugation via the dilithium salt of the N-t-butyloxycarbonyl-protected intermediate (6). Substitution of the intermediate with alkylating agents or an aldehyde gave predominantly a-alkylated products but chlorination with N-chlorosuccinimide provided a route to the &#947;-substituted unsaturated amino acid (13a). 
ER  -

