
%0 Journal Article
%A Allan, RD 
%A Johnston, GAR 
%A Kazlauskas, R 
%A Tran, H 
%T Synthesis of analogues of GABA. IX. 5-(Aminomethyl)-3-hydroxyfuran-2(5H)-one
%J Australian Journal of Chemistry
%D 1983/05/01
%V 36
%N 5
%P 977-981
%K 
%R https://doi.org/10.1071/CH9830977
%U https://www.publish.csiro.au/paper/CH9830977 
%X 5-(Aminomethyl)-3-hydroxyfuran-2(5H)-one (4) has been synthesized as a GABA analogue in five steps from hex-3-enedioic acid, the enolic &#945;-keto group being introduced under mild conditions by means of a singlet oxygen cleavage of an enamino lactone. The compound showed negligible activity as a GABA agonist with respect to inhibition of [3H]GABA binding, uptake and trans amination in rat brain membranes 
