
%0 Journal Article
%A Allan, RD 
%A Fong, J 
%T Synthesis of analogues of GABA. X. The bicyclic &#946;-diketone Octahydro-1H-2-pyrindine-5,7-dione
%J Australian Journal of Chemistry
%D 1983/06/01
%V 36
%N 6
%P 1221-1226
%K 
%R https://doi.org/10.1071/CH9831221
%U https://www.publish.csiro.au/paper/CH9831221 
%X The synthesis is described of octahydro-1H-2-pyrindine-5,7-dione (4) and its 6-diazo and 6-bromo derivatives. These are analogues of GABA in which the carboxyl group is replaced by an enolic &#946;-diketone. The compounds showed negligible or very weak activity as GABA agonists with respect to inhibition of [3H] GABA binding, uptake and transamination in rat brain membranes. 
