
TY  - JOUR
A1  - Andrews, PR 
A1  - Brownlee, RTC 
A1  - Mackay, MF 
A1  - Poulton, DB 
A1  - Sadek, M 
A1  - Winkler, DA 
T1  - Conformational analysis of picrotoxinin by N.M.R., X-ray crystallography, and molecular orbital and classical potential-energy calculations
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1983
VL  - 36
IS  - 11
SP  - 2219
EP  - 2225
KW  - 
UR  - https://doi.org/10.1071/CH9832219 
N2  - The conformation of the potent convulsant drug picrotoxinin has been studied by proton n.m.r., X-ray crystallography, molecular orbital calculations and classical calculations. The calculations reveal two alternative low-energy conformations, either of which is consistent with the n.m.r. data, and one of which is also observed crystallographically. The energy difference is sufficiently small to suggest that either conformation may be the biologically active form. 
ER  -

