
%0 Journal Article
%A Clarke, SI 
%A Kasum, B 
%A Prager, RH 
%A Ward, AD 
%T Central nervous system active compounds. XIII. The use of aminomethylene phthalides in the synthesis of phthalideisoquinoline alkaloids
%J Australian Journal of Chemistry
%D 1983/12/01
%V 36
%N 12
%P 2493-2498
%K 
%R https://doi.org/10.1071/CH9832493
%U https://www.publish.csiro.au/paper/CH9832493 
%X Dimethylaminomethyleneisobenzofuranones react with alkoxyphenylethylamines in aqueous acidic solution to give phthalide isoquinolines (tetrahydroisoquinolinylisobenzofuranones) in moderate yields. N-Methylation gives the naturally occurring phthalideisoquinoline alkaloids. A number of examples of this reaction sequence are reported, including the synthesis of (±)-cordrastine, (±)-corlumine and (±)-adlumine. 
