
%0 Journal Article
%A Paul, DB 
%T Heterocyclic analogues of phthalhydrazides: Cyclic hydrazides of pyridine 1-oxide and pyrazine 1,4-dioxide dicarboxylic acids
%J Australian Journal of Chemistry
%D 1984/01/01
%V 37
%N 1
%P 87-93
%K 
%R https://doi.org/10.1071/CH9840087
%U https://www.publish.csiro.au/paper/CH9840087 
%X The synthesis of N-oxides of the cyclic hydrazides of pyridine and pyrazine o-dicarboxylic acids is described. Pyrido[2,3-d]pyridazine-5,8-dione 1-oxide, pyrido[3,4-d]pyridazine-1,4-dione 6-oxide, and pyrazino[2,3-d]pyridazine-5,8-dione 1,2-dioxide, were obtained by direct oxidation of the parent hydrazides with peracetic acid. The pyridopyridazine derivatives were also unambiguously synthesized by treating the anhydrides or diesters of the relevant carboxylic acid 1-oxides with hydrazine hydrate. 
