
%0 Journal Article
%A Heinicke, G 
%A Hung, TV 
%A Prager, RH 
%A Ward, AD 
%T Central nervous system active compounds. XIV. On the cyclization of N-Acyl-N'-arylureas
%J Australian Journal of Chemistry
%D 1984/04/01
%V 37
%N 4
%P 831-844
%K 
%R https://doi.org/10.1071/CH9840831
%U https://www.publish.csiro.au/paper/CH9840831 
%X The cyclization of N-acyl-N'-arylureas in polyphosphoric acid has been reinvestigated. The product is not only the 4-substituted quinazolin-2(1H)-one as reported, but also contains the 2-acylaniline in major proportions. Two minor products have also been isolated. At 80º, an intermediate has been detected, the properties of which are consistent with it being the corresponding 2-acylphenyl- urea. Acyl ureas with strongly electron-withdrawing acyl groups form major amounts of the corresponding anilide by the formal loss of cyanic acid. The application of this reaction to the synthesis of quinazolinylphthalides has been investigated. 
