
TY  - JOUR
A1  - Heinicke, G 
A1  - Hung, TV 
A1  - Prager, RH 
A1  - Ward, AD 
T1  - Central nervous system active compounds. XIV. On the cyclization of N-Acyl-N'-arylureas
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1984
VL  - 37
IS  - 4
SP  - 831
EP  - 844
KW  - 
UR  - https://doi.org/10.1071/CH9840831 
N2  - The cyclization of N-acyl-N'-arylureas in polyphosphoric acid has been reinvestigated. The product is not only the 4-substituted quinazolin-2(1H)-one as reported, but also contains the 2-acylaniline in major proportions. Two minor products have also been isolated. At 80º, an intermediate has been detected, the properties of which are consistent with it being the corresponding 2-acylphenyl- urea. Acyl ureas with strongly electron-withdrawing acyl groups form major amounts of the corresponding anilide by the formal loss of cyanic acid. The application of this reaction to the synthesis of quinazolinylphthalides has been investigated. 
ER  -

