
%0 Journal Article
%A Deady, LW 
%T A synthesis of Benzo[c][1,8]naphthyridinones: an exception to the Knorr reaction
%J Australian Journal of Chemistry
%D 1984/05/01
%V 37
%N 5
%P 1135-1138
%K 
%R https://doi.org/10.1071/CH9841135
%U https://www.publish.csiro.au/paper/CH9841135 
%X The reaction of 1-methoxyisoquinolin-3-amine with ethyl acetoacetate, and subsequent ring closure, is reported. Conrad-Limpach synthesis leads to the expected 4(1H)-one. The same isomer is formed under Knorr conditions (hot polyphosphoric acid), while a less acidic medium (hot acetic acid) gives the 2(1H)-one. 
