
%0 Journal Article
%A Becker, AMRRW 
%T 3-Amino-5-hydroxybenzoic acid in antibiotic biosynthesis. VIII. Synthesis of chlorinated analogues
%J Australian Journal of Chemistry
%D 1984/10/01
%V 37
%N 10
%P 2103-2109
%K 
%R https://doi.org/10.1071/CH9842103
%U https://www.publish.csiro.au/paper/CH9842103 
%X The three isomeric ring monochlorinated derivatives of 3-amino-5-hydroxybenzoic acid (1), required for studies of the biosynthesis and synthesis of several important classes of antibiotics, are prepared from methyl 3-amino-5-hydroxybenzoate (5). N-Chlorosuccinimide selectively monochlorinates the 2- and 6-positions of this substrate, whilst perchlorination followed by hydrolysis and regiospecific protodechlorination at the 2- and 6-positions affords the 4-chloro acid. 
