
%0 Journal Article
%A Aliano, AN 
%A Allen, TE 
%A Brown, DJ 
%A Cowden, WB 
%A Grigg, GW 
%A Kavulak, D 
%A Lan, S 
%T Heterocyclic amplifiers of phleomycin. V. Thiadiazolylpyridines and related compounds; preliminary antitumour results
%J Australian Journal of Chemistry
%D 1984/11/01
%V 37
%N 11
%P 2385-2390
%K 
%R https://doi.org/10.1071/CH9842385
%U https://www.publish.csiro.au/paper/CH9842385 
%X Syntheses are described for N,N-dimethyl-2-[5'-(pyridin-2''-yl)-1',3',4'-thiadiazol-2'-ylthio]ethylamine; the homologous propylamine; the N,N-diethyl homologue; the 5'-phenyl analogue; and some substituted phenyl, pyrazinyl and pyrimidinyl analogues. Unlike the pyridin-4''-yl isomer previously described, these compounds proved but mediocre amplifiers of phleomycin-G in vitro against Escherichia coli. Testing in vivo against Ehrlich's tumour in mice was therefore confined to the pyridin-4''-yl compound and to N,N-dimethyl-2-(6'-methyl-2'-phenylpyrimidin-4'-ylthio)ethylamine: the first showed considerable amplifying power towards two phleomycins and a bleomycin; the second, only marginally less amplification towards the same phleomycins. 
