
TY  - JOUR
A1  - Aliano, AN 
A1  - Allen, TE 
A1  - Brown, DJ 
A1  - Cowden, WB 
A1  - Grigg, GW 
A1  - Kavulak, D 
A1  - Lan, S 
T1  - Heterocyclic amplifiers of phleomycin. V. Thiadiazolylpyridines and related compounds; preliminary antitumour results
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1984
VL  - 37
IS  - 11
SP  - 2385
EP  - 2390
KW  - 
UR  - https://doi.org/10.1071/CH9842385 
N2  - Syntheses are described for N,N-dimethyl-2-[5'-(pyridin-2''-yl)-1',3',4'-thiadiazol-2'-ylthio]ethylamine; the homologous propylamine; the N,N-diethyl homologue; the 5'-phenyl analogue; and some substituted phenyl, pyrazinyl and pyrimidinyl analogues. Unlike the pyridin-4''-yl isomer previously described, these compounds proved but mediocre amplifiers of phleomycin-G in vitro against Escherichia coli. Testing in vivo against Ehrlich's tumour in mice was therefore confined to the pyridin-4''-yl compound and to N,N-dimethyl-2-(6'-methyl-2'-phenylpyrimidin-4'-ylthio)ethylamine: the first showed considerable amplifying power towards two phleomycins and a bleomycin; the second, only marginally less amplification towards the same phleomycins. 
ER  -

