
%0 Journal Article
%A Barlin, GB 
%A Tan, W 
%T Potential antimalarials. II. N4-Substituted 2-Methoxy(and 2-hydroxy)-1,5-naphthyridin-4-amines
%J Australian Journal of Chemistry
%D 1984/12/01
%V 37
%N 12
%P 2469-2477
%K 
%R https://doi.org/10.1071/CH9842469
%U https://www.publish.csiro.au/paper/CH9842469 
%X Several new N4-substituted 2-methoxy(and 2-hydroxy)-1,5-naphthyridin-4-amines have been prepared from ethyl 3-aminopyridine-2-carboxylate. 2,4-Dichloro-1,5-naphthyridine with methanolic sodium methoxide gave 4-chloro-2-methoxy-1,5-naphthyridine but with methanolic hydrogen chloride afforded 4-chloro-1,5-naphthyridin-2-ol. The N4-substituted 1,5-naphthyridin-4-amines showed no significant antimalarial activity compared to chloroquine or primaquine in a preliminary in vivo screen against Plasmodium vinckei vinckei in mice. 
