
%0 Journal Article
%A Hickman, RJS 
%A Christie, BJ 
%A Guy, RW 
%A White, TJ 
%T Synthesis of Aromatic S-Sustituted Derivatives of <i>N</i>-Acetyl-L-cysteine
%J Australian Journal of Chemistry
%D 1985/06/01
%V 38
%N 6
%P 899-904
%K 
%R https://doi.org/10.1071/CH9850899
%U https://www.publish.csiro.au/paper/CH9850899 
%X A new method for the preparation of aromatic, S-substituted derivatives of N-acetyl-L- cysteine is described. The method involves nucleophilic substitution of aromatic iodides by N-acetyl-L- cysteine in the presence of copper(I) iodide, and provides the first example of nucleophilic substitution of unactivated aromatic halides by N-acetyl-L- cysteine . The method has been used to prepare N-acetyl-S-(2-thienyl)-L- cysteine and N-acetyl-S-(3-thienyl)-L- cysteine from 2-iodothiophen and 3-iodothiophen respectively. In addition, the method has been successfully applied to iodobenzene and 1-iodonaphthalene. A product yield of about 30% was obtained in each case. 
