
TY  - JOUR
A1  - Hickman, RJS 
A1  - Christie, BJ 
A1  - Guy, RW 
A1  - White, TJ 
T1  - Synthesis of Aromatic S-Sustituted Derivatives of <i>N</i>-Acetyl-L-cysteine
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1985
VL  - 38
IS  - 6
SP  - 899
EP  - 904
KW  - 
UR  - https://doi.org/10.1071/CH9850899 
N2  - A new method for the preparation of aromatic, S-substituted derivatives of N-acetyl-L- cysteine is described. The method involves nucleophilic substitution of aromatic iodides by N-acetyl-L- cysteine in the presence of copper(I) iodide, and provides the first example of nucleophilic substitution of unactivated aromatic halides by N-acetyl-L- cysteine . The method has been used to prepare N-acetyl-S-(2-thienyl)-L- cysteine and N-acetyl-S-(3-thienyl)-L- cysteine from 2-iodothiophen and 3-iodothiophen respectively. In addition, the method has been successfully applied to iodobenzene and 1-iodonaphthalene. A product yield of about 30% was obtained in each case. 
ER  -

