
%0 Journal Article
%A Barlin, G 
%A Tan, W 
%T Potential Antimalarials. IV. 4-[7'-Bromo(and Chloro)-1&#8242;,5&#8242;-Naphthyridin-4&#8242;-Ylamino]Phenols and N<sup>4</sup>-Substituted 7-Chloro-1,5-Naphthyridin-4-Amines
%J Australian Journal of Chemistry
%D 1985/06/01
%V 38
%N 6
%P 905-911
%K 
%R https://doi.org/10.1071/CH9850905
%U https://www.publish.csiro.au/paper/CH9850905 
%X A series of nine mono- and di-Mannich bases, for example 4-(7&#8242;-bromo-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino)-2,6-bis( dimethylaminomethyl )phenol derived from 4-(7&#8242;-bromo-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino)phenol and several other N4-substituted 7-bromo- and 7-chloro-1,5-naphthyridin-4- amines have been prepared. &#8242;All these compounds showed significant antimalarial activity when injected intraperitoneally in a single dose of 100-200 mg/kg to mice infected with Plasmodium vinckei vinckei. The di-Mannich bases appeared to be the most potent and effective in parasite control; however, no deaths were observed in infected mice treated with the mono- Mannich compounds. 
