
TY  - JOUR
A1  - Barlin, GB 
T1  - Heterocyclic Amplifiers of Phleomycin. VIII. Mono- Bis-(5'-substituted 1',3',4'-thiadiazol-2'-yl)pyridines and Mono(5'-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1985
VL  - 38
IS  - 10
SP  - 1491
EP  - 1497
KW  - 
UR  - https://doi.org/10.1071/CH9851491 
N2  - A series of mono- and bis -(5&#8242;-substituted 1&#8242;,3&#8242;,4&#8242;-thiadiazol-2&#8242;- yl )pyridines with strongly basic side chains, e.g., 3,5-bis[5&#8242;(2&#8242;-N,N- dimethylaminoethylthio )-1&#8242;,3&#8242;,4&#8242;-thiadiazol-2&#8242;-yl]pyridine (1), and (5?-substituted 1&#8242;,3&#8242;,4&#8242;-thiadiazol-2&#8242;-ylmethyl)pyridines have been prepared for evaluation as amplifiers of phleomycin. Five of the six bis (5&#8242;-substituted 1&#8242;,3&#8242;,4&#8242;-thiadiazol-2&#8242;-yl)pyridines were themselves antibacterial under the test conditions, but compound (1) and the mono(5&#8242;-substituted 1&#8242;,3&#8242;,4&#8242;-thiadiazol-2&#8242;-yl)-pyridines and -methylpyridines displayed moderate two-to-three-star activity. 
ER  -

